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Tepeli, Y.I. (author), Seale, C.F. (author), P. Gonçalves, Joana (author)Motivation<br/><br/>Anti-cancer therapies based on synthetic lethality (SL) exploit tumour vulnerabilities for treatment with reduced side effects, by targeting a gene that is jointly essential with another whose function is lost. Computational prediction is key to expedite SL screening, yet existing methods are vulnerable to prevalent selection...journal article 2023
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Seale, C.F. (author), Tepeli, Y.I. (author), P. Gonçalves, Joana (author)Motivation<br/>Synthetic lethality (SL) between two genes occurs when simultaneous loss of function leads to cell death. This holds great promise for developing anti-cancer therapeutics that target synthetic lethal pairs of endogenously disrupted genes. Identifying novel SL relationships through exhaustive experimental screens is challenging,...journal article 2022