Biomarker identification for endometriosis as a target for real-time intraoperative fluorescent imaging: A new approach using transcriptomic analysis to broaden the search for potential biomarkers

Intra-operative fluorescent imaging of endometriosis could help to optimize surgical treatment. Potential biomarkers to use as target for endometriosis-binding fluorescent probes were identified using a new five-phase transcriptomics-based approach to broaden the search for biomarkers. Using publicly available datasets, a differentially...

Review and perspectives in quantum computing for partial differential equations in structural mechanics

Structural mechanics is commonly modeled by (systems of) partial differential equations (PDEs). Except for very simple cases where analytical solutions exist, the use of numerical methods is required to find approximate solutions. However, for many problems of practical interest, the computational cost of classical numerical solvers running on...

Mortality Attributable to Long-Term Exposure to Ambient Fine Particulate Matter: Insights from the Epidemiologic Evidence for Understudied Locations

Epidemiologic cohort studies have consistently demonstrated that long-term exposure to ambient fine particles (PM_2.5) is associated with mortality. Nevertheless, extrapolating results to understudied locations may involve considerable uncertainty. To explore this issue, this review discusses the evidence for (i) the associated risk...

FLASH radiotherapy: ultra-high dose rates to spare healthy tissue

A recent addition to the treatment options in external beam therapy, so-called FLASH radiotherapy, shows remarkable healthy-tissue-sparing properties in a number of pre-clinical studies without impacting the overall treatment efficacy. Its potential in clinical applications is attracting a great deal of interest in the medical community. The...