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Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the <sup>99</sup>Mo/<sup>99m</sup>Tc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was...journal article 2022
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Wang, R. (author), Ponsard, Bernard (author), Wolterbeek, H.T. (author), Denkova, A.G. (author)Background: Radionuclide therapy (RNT) has become a very important treatment modality for cancer nowadays. Comparing with other cancer treatment options, sufficient efficacy could be achieved in RNT with lower toxicity. β<sup>−</sup> emitters are frequently used in RNT due to the long tissue penetration depth of the β<sup>−</sup> particles....journal article 2022
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Ma, C. (author), Vasileiadis, A. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The potential of the metal–organic framework UiO-66 and its functionalized derivatives for their utilization in the <sup>99</sup>Mo/<sup>99m</sup>Tc generator was assessed. Molybdenum adsorption experiments, structure characterization, molecular simulations and column experiments with molybdenum-99 were carried out. The results showed that...journal article 2021
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Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)In order to determine the potential of <sup>177m</sup>Lu/<sup>177</sup>Lu radionuclide generator in <sup>177</sup>Lu production it is important to establish the technical needs that can lead to a clinically acceptable <sup>177</sup>Lu product quality. In this work, a model that includes all the processes and the parameters affecting the...journal article 2020
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Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Background In this work, a lutetium-177 (177Lu) production method based on the separation of nuclear isomers, 177mLu & 177Lu, is reported. The 177mLu-177Lu separation is performed by combining the use of DOTA & DOTA-labelled peptide (DOTATATE) and liquid-liquid extraction. Methods The 177mLu cations were complexed with DOTA &...journal article 2019