Imaging DNA nanostructures with advanced TEM techniques

The low contrast of biomolecules in TEM has been a great obstacle for their structure determination and hence to the understanding of their structure-function relation. Historically, single DNA strands remained one the most difficult classes of biomolecular specimens to image, due to low electron scattering strength of its constituent elements....

Making Better Batteries: Following Electrochemistry at the Nano Scale with Electron Microscopy

With the focus in automobile industry to switch from petroleum-based vehicles to all electric vehicles, the increasing demand on harvesting energy from renewable sources for a safer and greener future and the ever-increasing demand of the portable electronics systems, the need for better batteries is eminent. The ultimate aim of battery research...

In-situ Transmission Electron Microscopy Studies on Graphene

Towards high resolution operando electron microscopy of a working catalyst

The objectives of this PhD project are to address the challenges of in-situ TEM and introduce a new generation of in-situ TEM equipment. In Chapter 2 the in-situ TEM facilities are introduced, focusing on the nanoreactor that has gone through quite some development stages during this project. Several types of in-situ TEM nanoreactors were...

Modeling of Image Formation in Cryo-Electron Microscopy

Knowledge of the structure of biological specimens is crucial for understanding life. Cryo-electron microscopy (cryo-EM) permits structural studies of biological specimen at their near-native state. The research performed in this thesis represents one of two subprojects of the FOM industrial partnership program with FEI Company. The common aim...

In situ Electrical measurements in Transmission Electron Microscopy

In the present thesis the combination of real-time electricalmeasurements on nano-sampleswith simultaneous examination by transmission electron microscope (TEM) is discussed. Application of an electrical current may lead to changes in the samples thus the possibility to correlate such changes with the corresponding I-V measurements is very...

Development of Quantitative electron nano-diffraction

This thesis is a step towards development of quantitative parallel beam electron nano-diffraction (PBED). It is focused on the superstructure determination of zig-zag and zig-zig NaxCoO2 and analysis of charge distribution in the two polymorphs Nb12O29 using PBED. It has been shown that quantitative electron nano-diffraction (parallel beam) has...