Developing a microfluidic device incorporating submicron topographies for studying bone regeneration

A major challenge facing the study of bone regeneration today is the inability to mimic the tissue microenvironment and the factors comprising it. Organ-on-chip based microfluidic systems today aim at doing so by dynamically culturing living cells in them. These are preferred owing to their small feature sizes, laminar flows, high throughput,...

A Hard Constraint Algorithm to Model Particle Interactions in DNA-laden Micro Flows

We present a new method for particle interactions in polymer models of DNA. The DNA is represented by a bead-rod polymer model. The main objective in this work is to implement short range forces to properly model polymer-polymer and polymer-surface interactions. We will discuss two methods for these interactions: (1) a new rigid constraint...