Flexure Design Optimization for Foldable Structures: Pseudo-Rigid Body Modeling and Multi-Objective Optimization

Compliant mechanisms have found their way in more and more applications in recent years, particularly in the aerospace and microsystems sectors. The benefits of compliant mechanisms stretch far, and can be exploited for large scale applications as well. Little research has been performed on the use of compliant mechanisms in large scale...

Topology optimization as architectural form finding: Using structural topology optimization to generate architectural geometry

Building with earthy materials requires new methods to generate architectural geometry and possibly buildings. Topology optimization is a process often used in mechanical engineering and minimizes the volume while still keeping the maximum stiffness. This research implements this process into architectural models, in order to find geometry based...

Classifying Candida species using Mixed Integer Optimization based optimal classification trees

Global medical use of azole antifungals and echinocandins has led to an enormous increase in resistant <i>Candida</i> species, that are most commonly associated with fungal infections. A possible mechanism causing resistance are single or simultaneous point mutations in the genes responsible for encoding antifungal target enzymes. The aim of...

Profit Optimization in Express Networks

Parcel delivery companies offer time-guaranteed transportation of parcels, letters and packages, picked up at one customer and delivered at another. The time in which this has to be done depends on the service level that the customer pays for. To transport the parcels, a network is used consisting of facilities and links, where the facilities...

Automatic Selection of an Optimal Power Plant Configuration: Using Client Preferences and time based Operational Profiles

Vessels are becoming more and more optimized towards their mission and an increasing amount of systems are considered during this optimization. Most of these considerations occur at an early design stage, where data is scarce and their impact is large. <br/>This research aims to aid designers in considering this growing forest of possible system...