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Isaakidou, A. (author), Ganjian, M. (author), van Hoften, R. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Groetsch, A. (author), Wątroba, M. (author), Schwiedrzik, J. (author), Mirzaali, Mohammad J. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects. Cochlear implants offer a potential solution by providing localized and sustained drug delivery to the cochlea. While the mechanical characterization of both the implants and their...journal article 2024
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4D printed shape-shifting biomaterials for tissue engineering and regenerative medicine applicationsKalogeropoulou, Maria (author), Diaz Payno, P.J. (author), Mirzaali, Mohammad J. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The existing 3D printing methods exhibit certain fabrication-dependent limitations for printing curved constructs that are relevant for many tissues. Four-dimensional (4D) printing is an emerging technology that is expected to revolutionize the field of tissue engineering and regenerative medicine (TERM). 4D printing is based on 3D printing,...review 2024
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Eijkel, B.I.M. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The antibacterial biofunctionality of bone implants is essential for the prevention and treatment of implant-associated infections (IAI). In vitro co-culture models are utilized to assess this and study bacteria-host cell interactions at the implant interface, aiding our understanding of biomaterial and the immune response against IAI without...review 2024
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Yarali, E. (author), Klimopoulou, M. (author), David, M.K. (author), Boukany, P. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author), Accardo, A. (author), Mirzaali, Mohammad J. (author)The Poisson's ratio and elastic modulus are two parameters determining the elastic behavior of biomaterials. While the effects of elastic modulus on the cell response is widely studied, very little is known regarding the effects of the Poisson's ratio. The micro-architecture of meta-biomaterials determines not only the Poisson's ratio but...journal article 2024
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Salandova, M. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)This study proposes a new concept for an on-demand drug releasing device intended for integration into additively manufactured (i.e., 3D printed) orthopedic implants. The system comprises a surface with conduits connected to a subsurface reservoir used for storage and on-demand release of antimicrobial agents, covered with a cap that prevents...journal article 2024
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van Hengel, I.A.J. (author), van Dijk, B. (author), Modaresifar, K. (author), Hooning van Duyvenbode, J. Fred F. (author), Nurmohamed, F. Ruben H.A. (author), Leeflang, M.A. (author), Fluit, A.C. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Weinans, Harrie (author), Zadpoor, A.A. (author)Additively manufactured (AM) porous titanium implants may have an increased risk of implant-associated infection (IAI) due to their huge internal surfaces. However, the same surface, when biofunctionalized, can be used to prevent IAI. Here, we used a rat implant infection model to evaluate the biocompatibility and infection prevention...journal article 2023
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Isaakidou, A. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global population. Current treatments using the systemic administration of drugs are therapeutically ineffective due to the anatomy of the cochlea and the existing blood–labyrinth barrier. Local drug delivery systems can ensure therapeutic drug concentrations locally...journal article 2023
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Garmendia Urdalleta, A. (author), van Poll, M.A. (author), Fahy, Niamh (author), Witte-Bouma, Janneke (author), van Wamel, Willem (author), Apachitei, I. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author), Farrell, Eric (author)Macrophage responses following the implantation of orthopaedic implants are essential for successful implant integration in the body, partly through intimate crosstalk with human marrow stromal cells (hMSCs) in the process of new bone formation. Additive manufacturing (AM) and plasma electrolytic oxidation (PEO) in the presence of silver...journal article 2023
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Callens, S.J.P. (author), Fan, D. (author), van Hengel, I.A.J. (author), Minneboo, M.B. (author), Diaz Payno, P.J. (author), Stevens, Molly M. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Individual cells and multicellular systems respond to cell-scale curvatures in their environments, guiding migration, orientation, and tissue formation. However, it remains largely unclear how cells collectively explore and pattern complex landscapes with curvature gradients across the Euclidean and non-Euclidean spectra. Here, we show that...journal article 2023
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Putra, N.E. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Dong, J. (author), Taheri, P. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Mol, J.M.C. (author), Chang, J. (author), Zhou, J. (author), Zadpoor, A.A. (author)The development of biodegradable Fe-based bone implants has rapidly progressed in recent years. Most of the challenges encountered in developing such implants have been tackled individually or in combination using additive manufacturing technologies. Yet not all the challenges have been overcome. Herein, we present porous FeMn-akermanite...journal article 2023
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Cruz Saldivar, M. (author), Tay, E.T.W.S. (author), Isaakidou, A. (author), Moosabeiki, Vahid (author), Fratila-Apachitei, E.L. (author), Doubrovski, E.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Durable interfacing of hard and soft materials is a major design challenge caused by the ensuing stress concentrations. In nature, soft-hard interfaces exhibit remarkable mechanical performance, with failures rarely happening at the interface. Here, we mimic the strategies observed in nature to design efficient soft-hard interfaces. We base...journal article 2023
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Cruz Saldivar, M. (author), Veeger, Robin Petrus Elias (author), Tay, E.T.W.S. (author), Fenu, M. (author), Klimopoulou, M. (author), van Osch, G.J.V.M. (author), Fratila-Apachitei, E.L. (author), Doubrovski, E.L. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)Living organisms use functional gradients (FGs) to interface hard and soft materials (e.g., bone and tendon), a strategy with engineering potential. Past attempts involving hard (or soft) phase ratio variation have led to mechanical property inaccuracies because of microscale-material macroscale-property nonlinearity. This study examines 3D...journal article 2023
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Putra, N.E. (author), Leeflang, M.A. (author), Ducret, Verena (author), Patrulea, Viorica (author), Fratila-Apachitei, E.L. (author), Perron, Karl (author), Ye, Hua (author), Zhou, J. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Implant-associated infections are highly challenging to treat, particularly with the emergence of multidrug-resistant microbials. Effective preventive action is desired to be at the implant site. Surface biofunctionalization of implants through Ag-doping has demonstrated potent antibacterial results. However, it may adversely affect bone...journal article 2022
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Ganjian, M. (author), Janbaz, S. (author), van Manen, T. (author), Tümer, N. (author), Modaresifar, K. (author), Minneboo, M.B. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)We designed and fabricated a simple setup for the controlled crumpling of nanopatterned, surface-porous flat metallic sheets for the fabrication of volume-porous biomaterials and showed that crumpling can be considered as an efficient alternative to origami-inspired folding. Before crumpling, laser cutting was used to introduce pores to the...journal article 2022
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Dong, J. (author), Lin, P. (author), Putra, N.E. (author), Tümer, N. (author), Leeflang, M.A. (author), Huan, Z. (author), Fratila-Apachitei, E.L. (author), Chang, J. (author), Zadpoor, A.A. (author), Zhou, J. (author)The treatment of femoral nonunion with large segmental bone defect is still challenging. Although magnesium alloys have been considered potential materials for such a treatment, their application is limited by their fast degradation. Adding bioceramic particles into magnesium to form Mg-matrix composites is a promising strategy to adjust...journal article 2022
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Angeloni, L. (author), Popa, Bogdan (author), Nouri Goushki, M. (author), Minneboo, M.B. (author), Zadpoor, A.A. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author)Physical patterns represent potential surface cues for promoting osteogenic differentiation of stem cells and improving osseointegration of orthopedic implants. Understanding the early cell–surface interactions and their effects on late cellular functions is essential for a rational design of such topographies, yet still elusive. In this work...journal article 2022
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San, H. (author), Paresoglou, M. (author), Minneboo, M.B. (author), van Hengel, I.A.J. (author), Yilmaz, A. (author), Gonzalez Garcia, Y. (author), Fluit, Ad C. (author), Hagedoorn, P.L. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)Nanoparticles (NPs) have high multifunctional potential to simultaneously enhance implant osseointegration and prevent infections caused by antibiotic-resistant bacteria. Here, we present the first report on using plasma electrolytic oxidation (PEO) to incorporate different combinations of reduced graphene oxide (rGO) and silver (Ag) NPs on...journal article 2022
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Modaresifar, K. (author), Ganjian, M. (author), Diaz Payno, P.J. (author), Klimopoulou, M. (author), Koedam, Marijke (author), van der Eerden, B.C.J. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Black Ti (bTi) surfaces comprising high aspect ratio nanopillars exhibit a rare combination of bactericidal and osteogenic properties, framing them as cell-instructive meta-biomaterials. Despite the existing data indicating that bTi surfaces induce osteogenic differentiation in cells, the mechanisms by which this response is regulated are not...journal article 2022
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Putra, N.E. (author), Borg, K. G.N. (author), Diaz Payno, P.J. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Taheri, P. (author), Mol, J.M.C. (author), Fratila-Apachitei, E.L. (author), Zhou, J. (author), Zadpoor, A.A. (author)Advanced additive manufacturing techniques have been recently used to tackle the two fundamental challenges of biodegradable Fe-based bone-substituting materials, namely low rate of biodegradation and insufficient bioactivity. While additively manufactured porous iron has been somewhat successful in addressing the first challenge, the limited...journal article 2022
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Diaz Payno, P.J. (author), Kalogeropoulou, Maria (author), Muntz, I.A.A. (author), Kingma, Esther (author), Kops, Nicole (author), D'Este, Matteo (author), Koenderink, G.H. (author), Fratila-Apachitei, E.L. (author), van Osch, G.J.V.M. (author), Zadpoor, A.A. (author)3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time-dependent stimuli-induced transformation, enables the fabrication of shape-changing constructs. Here, a 4D biofabrication method is reported for cartilage...journal article 2022