An operational simulation framework for modelling the multi-interaction of two-wheelers on mixed-traffic road segments

In recent years, the interest in riding in cities using the two-wheeler (e.g., bicycles, electric bicycles, electric mopeds, etc.) increases. Mixed-traffic road segments are one of the most common traffic scenes where the mixed two-wheeler flows exist. Because the movements are often not restricted by lanes, the two-wheeler uses lateral road...

Tailoring the flow properties of inhaled micronized drug powders by atomic and molecular layer deposition

For dry powder inhaled formulations, good flow behaviour is vital in re-dispersing the powder. However, inhaled drug powders with a particle size below 10 µm are classified as highly cohesive materials with poor flow characteristics. Here we demonstrate how to alter the flow properties of micronized budesonide powders by depositing different...

Drug powders with tunable wettability by atomic and molecular layer deposition: From highly hydrophilic to superhydrophobic

The wettability of pharmaceuticals is a key physical property which influences their dissolution rate, dispersibility, flowability and solid-state stability. Here, we provide a platform of surface nanoengineering methods capable of tuning the wettability of drug powders from high hydrophilicity to superhydrophobicity with drug loadings up to...

Controlled Pulmonary Delivery of Carrier-Free Budesonide Dry Powder by Atomic Layer Deposition

Ideal controlled pulmonary drug delivery systems provide sustained release by retarding lung clearance mechanisms and efficient lung deposition to maintain therapeutic concentrations over prolonged time. Here, we use atomic layer deposition (ALD) to simultaneously tailor the release and aerosolization properties of inhaled drug particles...

Design exploration of quantitative performance and geometry typology for indoor arena based on self-organizing map and multi-layered perceptron neural network

During the early design process, simulations allow numeric assessment and 3D models allow visual inspection for qualitative criteria. However, exploring different design alternatives based on both is challenging. To support the design exploration of quantitative performance and geometry typology of various design alternatives during the early...

High performance mixed potential type No₂ gas sensor based on porous YSZ layer formed with graphite doping

High performance mixed potential type NO₂ sensors using porous yttria-stabilized zirconia (YSZ) layers doped with different concentration graphite as solid electrolyte and LaFeO₃ as sensing electrode were fabricated and characterized. LaFeO₃ was prepared by a typical citrate sol–gel method and characterized...

Dynamic analysis of layered systems under a moving harmonic rectangular load based on the spectral element method

In order to design high-performance roadways, a robust tool which can compute the structural response caused by moving vehicles is necessary. Therefore, this paper proposes a spectral element method-based model to accurately and effectively predict the 3D dynamic response of layered systems under a moving load. A layer spectral element and a...

Research Note: Near-surface layer replacement for sparse data: Is interpolation needed?

Near-surface problem is a common challenge faced by land seismic data processing, where often, due to near-surface anomalies, events of interest are obscured. One method to handle this challenge is near-surface layer replacement, which is a wavefield reconstruction process based on downward wavefield extrapolation with the near-surface...

The minimum wind speed for sustainable turbulence in the nocturnal boundary layer

The collapse of turbulence in the nocturnal boundary layer is studied by means of a simple bulk model that describes the basic physical interactions in the surface energy balance. It is shown that for a given mechanical forcing, the amount of turbulent heat that can be transported downward is limited to a certain maximum. In the case of weak...

The three-dimensional flow organization past a micro-ramp in a supersonic boundary layer

The three-dimensional instantaneous flow organization in the near wake of a micro-ramp interacting with a Mach 2.0 supersonic turbulent boundary layer is studied using tomographic particle image velocimetry. The mean flow reveals a wake with approximately circular cross section dominated by a pair of counter-rotating streamwise vortices...