Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface

An efficient potential contrast agent for MRI

Journal article (2010)
Department
Biotechnology (AS) (TU Delft)
Copyright: © 2010 The Author(s); Royal Society of Chemistry
DOI: https://doi.org/doi:10.1039/c0cc00107d
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Published Date

13-05-2010

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Source:

Chemical Communications, 46 (24), 2010

Faculty

Applied Sciences

Department

Biotechnology

Abstract

Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.

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