Synthetic Biology for Multiscale Designed Biomimetic Assemblies

Title

Synthetic Biology for Multiscale Designed Biomimetic Assemblies: From Designed Self-Assembling Biopolymers to Bacterial Bioprinting

 Author

Majerle, Andreja (National Institute of Chemistry, Ljubljana)
Schmieden, D.T. (TU Delft BN/Marie-Eve Aubin-Tam Lab; Kavli institute of nanoscience Delft)
Jerala, Roman (National Institute of Chemistry, Ljubljana)
Meyer, Anne S. (University of Rochester)

Date

2019

 Abstract

Nature is based on complex self-assembling systems that span from the nanoscale to the macroscale. We have already begun to design biomimetic systems with properties that have not evolved in nature, based on designed molecular interactions and regulation of biological systems. Synthetic biology is based on the principle of modularity, repurposing diverse building modules to design new types of molecular and cellular assemblies. While we are currently able to use techniques from synthetic biology to design self-assembling molecules and re-engineer functional cells, we still need to use guided assembly to construct biological assemblies at the macroscale. We review the recent strategies for designing biological systems ranging from molecular assemblies based on self-assembly of (poly)peptides to the guided assembly of patterned bacteria, spanning 7 orders of magnitude.


 To reference this document use:

http://resolver.tudelft.nl/uuid:41ba991f-88f0-4d80-9bb5-fe2b5147d83e

 DOI

https://doi.org/10.1021/acs.biochem.8b00922

 Embargo date

2020-04-08

 ISSN

0006-2960

 Source

Biochemistry, 58 (16), 2095-2104

 Bibliographical note

Accepted Author Manuscript

 Part of collection

Institutional Repository

 Document type

journal article

 Rights

© 2019 Andreja Majerle, D.T. Schmieden, Roman Jerala, Anne S. Meyer
Files
PDF Majerle_manuscript_2019_clean.pdf 2.06 MB
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