Integrated visualization of multi-angle bioluminescence imaging and micro CT

Integrated visualization of multi-angle bioluminescence imaging and micro CT

Kok, P.
Dijkstra, J.
Botha, C.P.
Post, F.H.
Kaijzel, E.
Que, I.
Löwik, C.W.G.M.
Reiber, J.H.C.
Lelieveldt, B.P.F.

Electrical Engineering, Mathematics and Computer Science

Visualization Group

2007-03-06

This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI data. Also, an intuitive 3D landmark selection is developed to enable fast BLI / CT registration. Three modes of fused BLI / CT visualization were developed: slice visualization, carousel visualization and 3D surface visualization. The added value of the fused visualization is demonstrated in three small-animal experiments, where the sensitivity of BLI to detect cell clusters is combined with anatomical detail from micro-CT imaging.

Bioluminescence imaging
Micro CT
small animal imaging
image fusion
registration
data visualization

http://resolver.tudelft.nl/uuid:4accd1cf-b750-49b4-8123-10a110d5909d

SPIE

0277-786X

Proceedings of SPIE, 2007 vol. 6509

Institutional Repository

conference paper

(c)2007 Kok, P., Dijkstra, J., Botha, C.P., Post, F.H., Kaijzel, E., Que, I., Löwik, C.W.G.M., Reiber, J.H.C., Lelieveldt, B.P.F.