Integrated visualization of multi-angle bioluminescence imaging and micro CT

Conference paper (2007)
Department
Visualization Group (EEMCS) (TU Delft)
Copyright: ©2007 Kok, P., Dijkstra, J., Botha, C.P., Post, F.H., Kaijzel, E., Que, I., Löwik, C.W.G.M., Reiber, J.H.C., Lelieveldt, B.P.F.
Data visualization Image fusion Registration Micro CT Small animal imaging Bioluminescence imaging
More Info
expand_more

Published Date

06-03-2007

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Source:

Proceedings of SPIE, 2007 vol. 6509

ISSN:

0277-786X

Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Visualization Group

Abstract

This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI data. Also, an intuitive 3D landmark selection is developed to enable fast BLI / CT registration. Three modes of fused BLI / CT visualization were developed: slice visualization, carousel visualization and 3D surface visualization. The added value of the fused visualization is demonstrated in three small-animal experiments, where the sensitivity of BLI to detect cell clusters is combined with anatomical detail from micro-CT imaging.