Print Email Facebook Twitter Conformation and Dynamics of DNA Confined in Slitlike Nanofluidic Channels Title Conformation and Dynamics of DNA Confined in Slitlike Nanofluidic Channels Author Bonthuis, D.J. Meyer, C. Stein, D. Dekker, C. Faculty Applied Sciences Department Kavli Institute of Nanoscience Delft Date 2008-09-05 Abstract Using laser fluorescence microscopy, we study the shape and dynamics of individual DNA molecules in slitlike nanochannels confined to a fraction of their bulk radius of gyration. With a confinement size spanning 2 orders of magnitude, we observe a transition from the de Gennes regime to the Odijk regime in the scaling of both the radius of gyration and the relaxation time. The radius of gyration and the relaxation time follow the predicted scaling in the de Gennes regime, while, unexpectedly, the relaxation time shows a sharp decrease in the Odijk regime. The radius of gyration remains constant in the Odijk regime. Additionally, we report the first measurements of the effect of confinement on the shape anisotropy. To reference this document use: http://resolver.tudelft.nl/uuid:4be0798b-b9b8-41a4-8314-3f406290951f Publisher American Physical Society ISSN 1079-7114 Source Physical Review Letters, 101 (10), 2008 Part of collection Institutional Repository Document type journal article Rights (c) 2008 Bonthuis, D.J. ; Meyer, C. ; Stein, D. ; Dekker, C. ; American Physical Society Files PDF Bonthuis_2008.pdf 332.51 KB Close viewer /islandora/object/uuid:4be0798b-b9b8-41a4-8314-3f406290951f/datastream/OBJ/view