Advances in the development of a novel method to be used in proteomics using gold nanobeads

Conference paper (2006)
Department
Quantitative Imaging Group (AS) (TU Delft)
Copyright: ©2006 Dietrich, H.R.C., Young, I.T., Garini, Y.
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Published Date

27-02-2006

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Source:

Proceedings of SPIE, 2006 vol. 6092

Faculty

Applied Sciences

Department

Quantitative Imaging Group

Abstract

The study of DNA-protein interactions is gaining increased attention due to their importance in cellular processes. Only a well-functioning interaction guaranties that such a process can take place without errors. So far, only a small percentage of these interactions have been unraveled, partially due to their complexity but also due to the fact that there are only a few techniques that permit the study of these interactions. In this report we describe the development of a research tool based on tethered bead motion and Resonance Light Scattering (RLS) from gold beads. This method permits the study of DNA-protein interactions and the screening of proteins binding to a specific DNA sequence.