3D-Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia

3D-Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia

Golafshan, Nasim (University Medical Center Utrecht; Universiteit Utrecht)
Willemsen, K. (University Medical Center Utrecht)
Kadumudi, Firoz Babu (Technical University of Denmark)
Vorndran, Elke (University of Würzburg)
Dolatshahi-Pirouz, Alireza (Technical University of Denmark)
Weinans, Harrie (TU Delft Biomaterials & Tissue Biomechanics; University Medical Center Utrecht)
van der Wal, Bart C.H. (University Medical Center Utrecht)
Malda, Jos (University Medical Center Utrecht; Universiteit Utrecht)
Castilho, Miguel (University Medical Center Utrecht; Universiteit Utrecht; Eindhoven University of Technology)

2021

Osteoarthritis of the hip is a painful and debilitating condition commonly occurring in humans and dogs. One of the main causes that leads to hip osteoarthritis is hip dysplasia. Although the current surgical methods to correct dysplasia work satisfactorily in many circumstances, these are associated with serious complications, tissue resorption, and degeneration. In this study, a one-step fabrication of a regenerative hip implant with a patient-specific design and load-bearing properties is reported. The regenerative hip implant is fabricated based on patient imaging files and by an extrusion assisted 3D printing process using a flexible, bone-inducing biomaterial. The novel implant can be fixed with metallic screws to host bone and can be loaded up to physiological loads without signs of critical permanent deformation or failure. Moreover, after exposing the hip implant to accelerated in vitro degradation, it is confirmed that it is still able to support physiological loads even after losing ≈40% of its initial mass. In addition, the osteopromotive properties of the novel hip implant is demonstrated as shown by an increased expression of osteonectin and osteocalcin by cultured human mesenchymal stem cells after 21 days. Overall, the proposed hip implant provides an innovative regenerative and mechanically stable solution for hip dysplasia treatment.

3D printing
bone implants
bone regeneration
hip dysplasia
load bearing
patient-specific implants

http://resolver.tudelft.nl/uuid:9da8dab3-8d15-4056-aff1-7786612ad214

https://doi.org/10.1002/adhm.202101051

2192-2640

Advanced Healthcare Materials, 10 (21)

Institutional Repository

journal article

© 2021 Nasim Golafshan, K. Willemsen, Firoz Babu Kadumudi, Elke Vorndran, Alireza Dolatshahi-Pirouz, Harrie Weinans, Bart C.H. van der Wal, Jos Malda, Miguel Castilho