Depth resolved quantitative profiling of stratum corneum lipids and water content using short-wave infrared spectroscopy

Conference paper (2018)

Authors

A. Ezerskaia Philips Research
S.F. Pereira ImPhys/Optics - AS
Paul Urbach ImPhys/Optics - AS
Babu Varghese Philips Research
Research Group
ImPhys/Optics (AS) (TU Delft)
Copyright: © 2018 A. Ezerskaia, S.F. Pereira, Paul Urbach, Babu Varghese
DOI: https://doi.org/10.1117/12.2291896
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Published Date

2018

Language

English

Reuse Rights

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Faculty

Applied Sciences

Department

ImPhys/Imaging Physics

Research Group

ImPhys/Optics

Abstract

We show the feasibility of short wave infrared spectroscopy combined with tape stripping as a simple and noninvasive method for the analysis of lipids and the degree of hydration as a function of depth in the stratum corneum. The spectroscopic method utilizes differential detection with three wavelengths 1720, 1750, and 1770 nm, corresponding to the lipid vibrational bands that lay "in between" the prominent water absorption bands. The results are compared with other biophysical devices such as Corneometer and Sebumeter.

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