Optical detection of single molecules in nanofluidic chips

Conference paper (2004)
Department
Quantitative Imaging Group (AS) (TU Delft)
Copyright: ©2004 Parikesit, G.O.F., Kutchoukov, V.G., Van Oel, W., Lung,G.L., Bossche, A., Young, I.T., Garini, Y.
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Published Date

04-08-2004

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Source:

Proceedings of SPIE, 2004 vol. 5515

Faculty

Applied Sciences

Department

Quantitative Imaging Group

Abstract

We present the latest progress on a novel technology for detecting and manipulating solution of single molecules in nanofluidic channels. This paper explains the design and fabrication of nanofluidic chip and its interface, molecule manipulation technique being used, and the optical detection method employed. Single molecule detections are performed using optical imaging as well as metal microelectrodes. The ultimate goal is to get high spatial and spectral resolutions that can lead to molecular identification.