Nanofabricated structures and microfluidic devices for bacteria

From techniques to biology

Review (2016)

Authors

F. Wu Kavli institute of nanoscience Delft, BN/Cees Dekker Lab - AS
C. Dekker BN/Cees Dekker Lab - AS , Kavli institute of nanoscience Delft
Research Group
BN/Cees Dekker Lab (AS) (TU Delft)
Copyright: © 2016 F. Wu, C. Dekker
DOI: https://doi.org/10.1039/c5cs00514k
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Published Date

2016

Language

English

Reuse Rights

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Faculty

Applied Sciences

Department

BN/Bionanoscience

Research Group

BN/Cees Dekker Lab

Abstract

Nanofabricated structures and microfluidic technologies are increasingly being used to study bacteria because of their precise spatial and temporal control. They have facilitated studying many long-standing questions regarding growth, chemotaxis and cell-fate switching, and opened up new areas such as probing the effect of boundary geometries on the subcellular structure and social behavior of bacteria. We review the use of nano/microfabricated structures that spatially separate bacteria for quantitative analyses and that provide topological constraints on their growth and chemical communications. These approaches are becoming modular and broadly applicable, and show a strong potential for dissecting the complex life of bacteria at various scales and engineering synthetic microbial societies.

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