Light-Driven Enzymatic Decarboxylation of Fatty Acids

Journal article (2018)

Authors

M.M.E. Huijbers BT/Biocatalysis - AS
W. Zhang BT/Biocatalysis - AS
F. Tonin BT/Biocatalysis - AS
F. Hollmann BT/Biocatalysis - AS
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2018 M.M.E. Huijbers, W. Zhang, F. Tonin, F. Hollmann
DOI: https://doi.org/10.1002/anie.201807119
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Published Date

2018

Language

English

Reuse Rights

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase from Chlorella variabilis NC64A (CvFAP) we demonstrate the irreversible preparation of alkanes from fatty acids and triglycerides. Several fatty acids and their triglycerides are converted by CvFAP in near-quantitative yield and exclusive selectivity upon illumination with blue light. Very promising turnover numbers of up to 8000 were achieved in this proof-of-concept study.

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