Sparsity maximization approach to multiple daily injections therapy for type 1 diabetic patients

Master thesis (2021)

Authors

M.F. van Wilsum Mechanical Engineering

Contributors

M. Mazo Team Manuel Mazo Jr - Mechanical, Maritime and Materials Engineering (supervisor 1)
Faculty
Mechanical Engineering
Copyright: © 2021 Max van Wilsum
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Published Date

14-07-2021

Language

English

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Faculty

Mechanical Engineering

Abstract

Based on sparsity maximization we propose a controller for Multiple Daily Injections (MDI)therapy for Type 1 Diabetes melitus (T1DM) individuals. Based on convex relaxations onthe sparsity maximization problems and by implementing personalised linear models of pa-tient we formulate a model predictive controller to determine insulin boluses. By relaxingthe constraints of the unsafe regions after meal consumption for pre-defined time interval weobtain sufficient performance with a long enough horizon. To improve the controllers perfor-mance a case-based reasoning framework is implemented to tune the controller constraintsfor increasing time spent in euglycemia.