Print Email Facebook Twitter Transcranial Direct Current Stimulation Targeting the Entire Motor Network Does Not Increase Corticospinal Excitability Title Transcranial Direct Current Stimulation Targeting the Entire Motor Network Does Not Increase Corticospinal Excitability Author van der Cruijsen, J. (TU Delft Biomechatronics & Human-Machine Control; Erasmus MC) Jonker, Z.D. (Erasmus MC; Rijndam Rehabilitation Centre) Andrinopoulou, Eleni Rosalina (Erasmus MC) Wijngaarden, Jessica E. (Student TU Delft; Erasmus MC) Tangkau, Ditte A. (Erasmus MC) Tulen, Joke H.M. (Erasmus MC) Frens, Maarten A. (Erasmus MC) Ribbers, G.M. (Erasmus MC; Rijndam Rehabilitation Centre) Selles, R.W. (Erasmus MC) Date 2022 Abstract Transcranial direct current stimulation (tDCS) over the contralateral primary motor cortex of the target muscle (conventional tDCS) has been described to enhance corticospinal excitability, as measured with transcranial magnetic stimulation. Recently, tDCS targeting the brain regions functionally connected to the contralateral primary motor cortex (motor network tDCS) was reported to enhance corticospinal excitability more than conventional tDCS. We compared the effects of motor network tDCS, 2 mA conventional tDCS, and sham tDCS on corticospinal excitability in 21 healthy participants in a randomized, single-blind within-subject study design. We applied tDCS for 12 min and measured corticospinal excitability with TMS before tDCS and at 0, 15, 30, 45, and 60 min after tDCS. Statistical analysis showed that neither motor network tDCS nor conventional tDCS significantly increased corticospinal excitability relative to sham stimulation. Furthermore, the results did not provide evidence for superiority of motor network tDCS over conventional tDCS. Motor network tDCS seems equally susceptible to the sources of intersubject and intrasubject variability previously observed in response to conventional tDCS. Subject corticospinal excitabilitymotor evoked potentialmotor networktDCSTMS To reference this document use: http://resolver.tudelft.nl/uuid:abb65c8d-524f-4d9d-87ff-4679bc4d8b0e DOI https://doi.org/10.3389/fnhum.2022.842954 ISSN 1662-5161 Source Frontiers in Human Neuroscience, 16 Part of collection Institutional Repository Document type journal article Rights © 2022 J. van der Cruijsen, Z.D. Jonker, Eleni Rosalina Andrinopoulou, Jessica E. Wijngaarden, Ditte A. Tangkau, Joke H.M. Tulen, Maarten A. Frens, G.M. Ribbers, R.W. Selles Files PDF fnhum_16_842954.pdf 677.08 KB Close viewer /islandora/object/uuid:abb65c8d-524f-4d9d-87ff-4679bc4d8b0e/datastream/OBJ/view