PWM-based Transthoracic Bioimpedance Analyzer for Detecting Heart Failures

Patients that suffer from heart failure can benefit from wearable monitoring devices that continuouslymonitor the condition of the heart. One of the foremost symptoms of exacerbation of the heart is fluidcongestion in the lungs. One of the method to measure a change in biological tissue, such as thebuild­up of fluids in the lungs and chest, is...

A 16-Channel CMOS Reconfigurable Recording Unit for Simultaneous In-Vitro Microelectrode Array and Current-Clamp Measurements

In-vitro cell culturing technique is widely used in many branches of science such as in neuroscience and cardiology to investigate the dynamics of large population of cells. Cultured cells can be studied by means of two fundamental recording techniques that are intracellular and extracellular recordings. Patch-clamp technique is the gold...

A 3-by-3 400-MHz LC microsensor array for wireless capacitive biosensing

Biosensing has been developed rapidly for a number of biomedical applications, including neural monitoring, protein detection, bacteria detection and blood glucose monitoring. Among the branches of bio-sensing, capacitive sensing is a promising technique and utilized widely, since it is rapid, simple, label free and inexpensive. Compared with...

Oscillator based Analog-to-Digital Converter for Action Potential Readout in Microelectrode Arrays

The functioning of the brain depends on the interplay between a large number of neurons. To understand the information processing in neuronal networks, we need tools to record the electrical activity of cells at high resolution. Microelectrode arrays (MEAs) are predominantly used to measure neuronal activity<br/>at high spatial and temporal...

PVT Tolerant Transconductor for Low-Voltage Highly-Selective High-Frequency Filter of MRI Front-end Receiver

MRI machine has evolved tremendously over the years from its inception in order to render high-quality 3D images, best among its companion imaging systems. Of the whole system, RF receiver is the most crucial for its noise performance, which is expected to provide high SNR at all operating conditions. At Philips, MRI’s RF receiver is based on...

Functional Characterization of Human iPSC-Derived Neural Networks using MEA Systems for in vitro Modeling of Psychiatric Disorders

Psychiatric disorders are associated with major societal, personal issues and comprise 13% of the global burden of disease. They are heritable and present a complex pathophysiology, characterized by hundreds of genetic variants which are cumulated together and provoke a specific psychiatric disorder. Although a considerable progress has been...

Novel microelectrode arrays for in-vitro analysis of neural activity

Microelectrode arrays (MEAs) are extensively used for measuring neural activity in-vitro given their ability to monitor several neurons simultaneously unlike techniques such as patch clamp. However, MEAs still have limitations in acquiring high spatial resolution data due to limited number of channels that can be parallelly scanned, the need for...

Impedance-Based Bioassay for Characterization of Single Malignant Melanoma Cancer Cells using Cmos-Mea Systems: A Heterogeneity and Classification Assay Proposal

Malignant Melanoma (MM) is the most aggressive type of skin-cancer. Current diagnostic tools for the detection of malignancies of the skin (MM cancer) include histological, optical, ultrasound, and impedance-based techniques. The inadequacies of the first three practices are overwhelmed by the Electrical Impedance Spectroscopy (EIS) method. EIS...