Emerging applications like cloud computing and big data analytics have created the need for powerful centers hosting hundreds of thousands of servers. Currently, the data centers are based on general purpose processors that provide high flexibility but lacks the energy efficiency of customized accelerators. VINEYARD1 aims to develop novel servers based on programmable hardware accelerators. Furthermore, VINEYARD will develop an integrated framework for allowing end-users to seamlessly utilize these accelerators in heterogeneous computing systems by using typical data-center programming frameworks (i.e. Spark). VINEYARD will foster the expansion of the soft-IP cores industry, currently limited in the embedded systems, to the data center market. VINEYARD plans to demonstrate the advantages of its approach in three real use-cases a) a bio-informatics application for high-accuracy brain modeling, b) two critical financial applications and c) a big-data analysis application.