This article presents an overview of how Artificial Intelligence (AI) and edge technology have been used to improve wireless connectivity in multiple industrial Use Cases (UCs) of the EU project “Intelligent Secure Trustable Things” (InSecTT). We present a brief introduction of the InSecTT framework for cross-domain architecture design, which targets UCs assisted by reusable and/or interoperable technical Building Blocks (BBs). These BBs constitute the “bricks” containing AI and supporting components that were used to build different UCs. The framework consists of multiple stages based on the processing of UC/BB requirements (RQs). These stages include collection, harmonization, refinement, classification, architecture alignment, and functionality modeling of RQs. The most relevant results of these stages are discussed here, with emphasis on the need for a refined granularity of technical components with common functionalities named Sub-Building blocks (SBBs), where collaboration and cross-domain reusability were optimized. The design process shed light on how AI and SBBs were implemented across different layers and entities of our reference architecture for the Internet-of-Things (IoT), including the interfaces used for information exchange. This detailed interface analysis is expected to reveal issues such as bottlenecks, constraints, vulnerabilities, scalability problems, security threats, etc. This will, in turn, contribute to identifying design gaps of AI-enabled IoT systems. The article summarizes the SBBs related to wireless connectivity, including a general description, implementation issues, a comparison of results, adopted interfaces, and conclusions across domains.