With the emerging climate change and nature degradation, solutions to the environmental challenges have to be implemented in various industries. The experiment method was undertaken to study symbiotic human and nature connection possibilities through the water and nutrient cycle. The purpose was to elevate the role of the building in enhancing biodiversity in the urban settlement and merge it with the context. The scope of the research paper touches on the building scale to decentralize the existing sanitation treatment in the Netherlands as an alternative solution for the water and nutrient cycle and create a more circular system. The result of the schematic diagram indicates the combination of flows that could benefit both humans and nature. Project “Building as a Landscape” as an example shows how to apply permaculture and low tech sanitation system in the existing building in the city. This way, the added new façade layer to the T4 government office building connects people waste with the nature flows through architecture that allows biota to be on the ground, façade and roof.