Soft robots' ability to safely navigate complex environments motivates the development of algorithms for accurate environmental interaction assessment, enabling greater autonomy. Specifically, strain-based shape and force estimation of continuum robots with embedded soft sensors poses an open challenge mainly owing to continuous softness, anisotropic deformation, and non-linear properties. Mathematical description of deformable soft bodies and accurate estimation of external forces are crucial for achieving controllable and intelligent behaviors of these robots. In this paper, a kinetostatic strain-based modeling for rod-driven soft robots (RDSR) with embedded stretch sensors is proposed, which incorporates local strains, actuation variables, and external interactions. The strain model enables full shape estimation of the robot and prediction of strain variations in soft bodies. Building on this, we develop a force estimator based on predicted and measured sensor and actuator lengths to evaluate 3D external forces, accounting for both orthogonal and tangential components relative to the backbone. Moreover, we introduce a methodology using a novel ellipsoid representation to handle tangential forces that may become insensitive in certain singular configurations. This estimator allows us to either disregard such forces when they do not influence deformation or estimate them when they become observable. Our simulations and experiments demonstrate how this approach can be used to analyze the robot's configuration and successfully estimate external forces. Finally, it is demonstrated that when the continuum arm follows trajectories with higher strain sensitivity, tangential force estimation is significantly improved.

Soft robots promise inherent safety via their material compliance for seamless interactions with humans or delicate environments. Yet, their development is challenging because it requires integrating materials, geometry, actuation, and autonomy into complex mechatronic systems. Despite progress, the field struggles to balance task-specific performance with broader factors like durability and manufacturability—a difficulty that we find is compounded by traditional sequential design processes with their lack of feedback loops. In this perspective, we review emerging co-design approaches that simultaneously optimize the body and brain, enabling the discovery of unconventional designs highly tailored to the given tasks. We then identify three key shortcomings that limit the broader adoption of such co-design methods within the soft robotics domain. First, many rely on simulation-based evaluations focusing on a single metric, while real-world designs must satisfy diverse criteria. Second, current methods emphasize computational modeling without ensuring feasible realization, risking sim-to-real performance gaps. Third, high computational demands limit the exploration of the complete design space. Finally, we propose a holistic co-design framework that addresses these challenges by incorporating a broader range of design values, integrating real-world prototyping to refine evaluations, and boosting efficiency through surrogate metrics and model-based control strategies. This holistic framework, by simultaneously optimizing functionality, durability, and manufacturability, has the potential to enhance reliability and foster broader acceptance of soft robotics, transforming human-robot interactions.