The HIsarna process is one of the emerging low-CO₂ ironmaking processes that could help the steel industry in achieving their carbon footprint goals. HIsarna hot metal contains 3–4 times more sulfur than hot metal from blast furnaces (BFs). Therefore, a literature study, a thermodynamic analysis, and plant data analysis from Tata Steel, IJmuiden, are used herein to investigate the consequences of HIsarna hot metal for the current hot metal desulfurization process. Although the high sulfur concentration and low temperature of HIsarna hot metal lead to a higher total reagent consumption, compared with desulfurization of BF hot metal, the specific magnesium consumption decreases. The higher oxygen concentration in HIsarna hot metal only leads to a small increase in reagent consumption.