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S.J. Howe

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4 records found

Insertional mutagenisis combined with acquiered somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Journal article - S.J. Howe, M.R. Mansour, K.C. Gilmour, S Adams, SI Thornhill, KL Parsley, FJT Staal, RE Gale, DC Linch, J Bayford, L Brown, M Quaye, K. Schwarzwaelder, C Kinnon, P Ancliff, DK Webb, M Schmidt, C von Kalle, H.B. Gaspar, A.J. Trasher, C. Bartholomae, M. Hubank, H. Kempski, MH Brugman, K Pike-Overzet, S.J. Chatters, D. de Ridder

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-x1 gene therapy

Journal article - A Deichmann, S Hacein-Bey-Abina, A Fischer, K. Schwarzwaelder, ML Siegler, D. de Ridder, K Pike-Overzet, S.J. Howe, AJ Thrasher, G Wagemaker, U Abel, FJT Staal, M Schmidt, E Delabesse, JL Villeval, B Aronow, C Hue, C Prinz, M Wissler, C Klanke, J Weissenbach, I Alexander, N Fischer, A Garrique, C Kalle von, M Cavazzana-Calvo, MH Brugman, J Hu, H Glimm, G Gyapay, B Prum, CC Fraser

Ectopic retroviral expression of LMO2, but not IL2Ry, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy

Journal article - K Pike-Overzet, D. de Ridder, JJM van Dongen, FJT Staal, F Weerkamp, MRM Baert, MMA Verstegen, MH Brugman, S.J. Howe, M.J.T. Reinders, AJ Thrasher, G Wagemaker