In order to cope with the rise in human-caused demands, Saudi Arabia is exploring new groundwater sources. The groundwater potential of Wadi Ranyah was studied using a multi-dataset-integrated approach that included time-variable gravity data from the Gravity Recovery and Climate Experiment (GRACE), vertical electrical sounding (VES), and time-domain-electromagnetic (TDEM) data with other related datasets to examine the variations and occurrence of groundwater storage and to define the controlling factors affecting the groundwater potential in Wadi Ranyah in southwestern Saudi Arabia. Between April 2002 and December 2021, the estimated variation in groundwater resources was −3.85 ± 0.15 mm/yr. From 2002 to 2019, the area observed an average yearly precipitation rate of 100 mm. The sedimentary succession and the underlying fractured basement rocks are influenced by the structural patterns that run mainly in three different trends (NW, NE, and NS). The sedimentary cover varies from 0 to 27 m in thickness. The outputs of the electrical sounding revealed four primary geoelectric units in the study area: on top, a highly resistant geoelectrical unit with a resistivity of 235–1020 Ω.m, composed of unsorted, loose, recent sediments; this is followed by a layer of gravel and coarse-grained sands with a resistivity of 225–980 Ω.m; then, a water-bearing unit of saturated sediments and weathered, fractured, basement crystalline rocks with a resistivity of 40–105 Ω.m, its depth varying from 4 to ~9 m; and then the lowest fourth unit composed of massive basement rocks with higher resistivity values varying from 4780 to 7850 Ω.m. The seven built dams store surface-water runoff in the southwestern part of the wadi, close to the upstream section, in addition to the Ranyah dam, as the eighth one is located in the middle of the wadi. The subsurface NW- and NS-trending fault lines impede the groundwater from flowing downstream of the wadi, forming isolated water-bearing grabens. Minimal surface runoff might occur in the northern part of the wadi. The combined findings are beneficial because they provide a complete picture of the groundwater potential of Wadi Ranyah and the controlling structural patterns. Using this integrated technique, the groundwater potential in arid and semiarid regions can now be accurately assessed.