The noise characteristics of YBa2Cu3O7-x films prepared by the laser ablation technique on SrTiO3 substrates were studied. The epitaxial YBCO films possess a perfect structure and are characterized by a narrow superconducting transition, strong pinning, and a very small flicker noise. In the normal state, the 1/f noise increases with the dislocation density. The minimum noise level with a Hooge parameter of (2-3) × 10-6 was observed at a disc location density of 8-12 μm-2.