Alexander Teumer

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Journal article (2)

2 records found

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Journal article (2024) - Rosalie B.T.M. Sterenborg, Inga Steinbrenner, More authors..., Yong Li, Melissa N. Bujnis, Tatsuhiko Naito, Eirini Marouli, Marcel E. Meima, Erik B. van den Akker, Alexander Teumer, Marco Medici

To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits. The loci explained 14.1%, 6.0%, 9.5% and 1.1% of the total variation in TSH, FT4, total T3 and free T3 concentrations, respectively. Genetic correlations indicate that TSH associated loci reflect the thyroid function determined by free T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases. ...

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Journal article (2016) - Hieab H H Adams, Derrek P. Hibar, Ashley H. Beecham, Lianne Schmaal, Andrew J. Schork, Li Shen, Jean Shin, Elena Shumskaya, Albert V. Smith, Emma Sprooten, Lachlan T. Strike, Alexander Teumer, Russell Thomson, Neda Jahanshad, Diana Tordesillas-Gutierrez, Roberto Toro, Daniah Trabzuni, Dhananjay Vaidya, Jeroen Van Der Grond, Dennis Van Der Meer, Marjolein M J Van Donkelaar, Kristel R. Van Eijk, Theo G M Van Erp, Daan Van Rooij, Katharina Wittfeld, Esther Walton, Lars T. Westlye, Christopher D. Whelan, Beverly G. Windham, Anderson M. Winkler, Girma Woldehawariat, Christiane Wolf, Thomas Wolfers, Bing Xu, Lisa R. Yanek, Sven J. Van Der Lee, Jingyun Yang, Alex Zijdenbos, Marcel P. Zwiers, Ingrid Agartz, Neelum T. Aggarwal, Laura Almasy, David Ames, Philippe Amouyel, Ole A. Andreassen, Sampath Arepalli, Lucija Abramovic, Amelia A. Assareh, Sandra Barral, Mark E. Bastin, Diane M. Becker, James T. Becker, David A. Bennett, John Blangero, Hans Van Bokhoven, Dorret I. Boomsma, Henry Brodaty, Saud Alhusaini, Rachel M. Brouwer, Han G. Brunner, Randy L. Buckner, Jan K. Buitelaar, Kazima B. Bulayeva, Wiepke Cahn, Vince D. Calhoun, Dara M. Cannon, Gianpiero L. Cavalleri, Christopher Chen, Najaf Amin, Ching Yu Cheng, Sven Cichon, Mark R. Cookson, Aiden Corvin, Benedicto Crespo-Facorro, Joanne E. Curran, Michael Czisch, Anders M. Dale, Gareth E. Davies, Eco J C De Geus, Micael Andersson, Philip L. De Jager, Greig I. De Zubicaray, Norman Delanty, Chantal Depondt, Anita L. Destefano, Allissa Dillman, Srdjan Djurovic, Gary Donohoe, Wayne C. Drevets, Ravi Duggirala, Konstantinos Arfanakis, Thomas D. Dyer, Susanne Erk, Thomas Espeseth, Denis A. Evans, Iryna O. Fedko, Guillén Fernández, Luigi Ferrucci, Simon E. Fisher, Debra A. Fleischman, Ian Ford, Benjamin S. Aribisala, Tatiana M. Foroud, Peter T. Fox, Clyde Francks, Masaki Fukunaga, J. Raphael Gibbs, David C. Glahn, Randy L. Gollub, Harald H H Göring, Hans J. Grabe, Robert C. Green, Vincent Chouraki, Nicola J. Armstrong, Oliver Gruber, Vilmundur Gudnason, Sebastian Guelfi, Narelle K. Hansell, John Hardy, Catharina A. Hartman, Ryota Hashimoto, Katrin Hegenscheid, Andreas Heinz, Stephanie Le Hellard, Lavinia Athanasiu, Dena G. Hernandez, Dirk J. Heslenfeld, Beng Choon Ho, Pieter J. Hoekstra, Wolfgang Hoffmann, Albert Hofman, Florian Holsboer, Georg Homuth, Norbert Hosten, Jouke Jan Hottenga, Tomas Axelsson, Hilleke E Hulshoff Pol, Masashi Ikeda, M. Kamran Ikram, Clifford R. Jack, Mark Jenkinson, Robert Johnson, Erik G. Jönsson, J. Wouter Jukema, René S. Kahn, Derek W. Morris, Alexa Beiser, Wiro J. Niessen, More Authors..., Manon Bernard, Joshua C. Bis, Laura M E Blanken, Susan H. Blanton, Marc M. Bohlken, Marco P. Boks, Jason L. Stein, Janita Bralten, Adam M. Brickman, Owen Carmichael, M. Mallar Chakravarty, Ganesh Chauhan, Qiang Chen, Christopher R K Ching, Gabriel Cuellar-Partida, Anouk Den Braber, Nhat Trung Doan, Paul A. Nyquist, Stefan Ehrlich, Irina Filippi, Tian Ge, Sudheer Giddaluru, Aaron L. Goldman, Rebecca F. Gottesman, Corina U. Greven, Oliver Grimm, Michael E. Griswold, Tulio Guadalupe, Miguel E. Rentería, Johanna Hass, Unn K. Haukvik, Saima Hilal, Edith Hofer, David Hoehn, Avram J. Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Dalia Kasperaviciute, Stella Trompet, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H. Lee, Jiemin Liao, David C M Liewald, Lorna M. Lopez, Michelle Luciano, Christine Macare, Andre Marquand, Alejandro Arias-Vasquez, Mar Matarin, Karen A. Mather, Manuel Mattheisen, Bernard Mazoyer, David R. McKay, Rebekah McWhirter, Yuri Milaneschi, Nazanin Mirza-Schreiber, Ryan L. Muetzel, Susana Muñoz Maniega, Sudha Seshadri, Kwangsik Nho, Allison C. Nugent, Loes M Olde Loohuis, Jaap Oosterlaan, Martina Papmeyer, Irene Pappa, Lukas Pirpamer, Sara Pudas, Benno Pütz, Kumar B. Rajan, Sylvane Desrivières, Adaikalavan Ramasamy, Jennifer S. Richards, Shannon L. Risacher, Roberto Roiz-Santiañez, Nanda Rommelse, Emma J. Rose, Natalie A. Royle, Tatjana Rundek, Philipp G. Sämann, Claudia L. Satizabal

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (genetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (N combined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits. ...