Palliative care is becoming increasingly important at Erasmus Medical Center (Erasmus MC) as the hospital sees around a thousand annual deaths due to various conditions. However, the hospital environment has not adequately addressed the psychological, spiritual, and social needs of patients and their loved ones during the end-of-life phase. This TU Delft graduation project, in collaboration with Erasmus MC, aims to explore the unique needs of patients, their families, medical staff and the patient environment in the final days of life. The goal is to develop a sustainable, design-driven concept that illustrates enhanced end-of-life care across different hospital departments. This research employed a multi-phase design approach using the Double Diamond framework. The Discover phase involved extensive research, including literature reviews, visits to care facilities, patient room analyses and interviews with healthcare professionals. The Define phase synthesized these insights into a framework for the End of Life journey, analyzing the needs and responsibilities of key stakeholders. This analysis led to a future vision, outlining three design directions for improved palliative care. In the Develop phase, a concept was teratively created and evaluated to align with this vision. The design process focused on the design goal: “To create a patient room that supports stakeholders in the End of Life process in facilitating a dignified end of life experience for all involved.” Finally, the Deliver phase presented a proof of concept to illustrate the possibilities of this research, with recommendations for future implementations at Erasmus MC. The research identified several key findings, categorized into three main design opportunities: improving communication and expectations, enhancing the autonomy of actors involved and balancing the wishes of patients with the resources of the medical team. “De Verhalenhoek" emerged from this process: a cabinet where patients can store meaningful items, facilitating conversations about values and interests between patients, loved ones and medical staff. The concept invites users to personalize the room and serves as a starting point for conversations about the End of Life process. De Verhalenhoek aligns with the goals by creating a welcoming space that encourages discussions about patients' values and the meaning of death, enhancing communication and quality of care. This helps to reveal individual, cultural and religious preferences, allowing medical staff to tailor treatments to patients' whishes and ensuring patients and loved ones feel seen and heard. The research concludes that integrating thoughtful design into patient rooms can improve communication in end-of-life phases and enhance the sense of autonomy for stakeholders involved. Key recommendations include evaluating the interactions through a pilot study to assess the impact in the intended setting. This pilot aims to help patients feel more in control and supported in their final days and to better prepare the loved ones for the grieving process. Future research should focus on implementing these design solutions across various hospital departments to broadly enhance the quality of palliative care at Erasmus MC. This project demonstrates the potential of design to improve End of Life care in patient rooms, making a contribution to the field of palliative care.