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PF Leadlay
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Authored
8 records found
A polylinker approach to reductive loop swaps in modular polyketide synthases
Journal article -
L Kellenberger
,
IS Galloway
,
G Sauter
,
G Böhm
,
U. Hanefeld
,
J Cortes
,
J Staunton
,
PF Leadlay
Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a biomodular polyketide synthase.
Journal article -
KJ Weissman
,
M Bycroft
,
PF Leadlay
,
AL Cutter
,
U. Hanefeld
,
EJ Frost
,
MC Timoney
,
RC Harris
,
S Handa
,
M Roddis
,
J Staunton
The thioesterase of the erythromycin-producing polyketide synthase: influence of acyl chain structure on the mode of release of substrate analogues from the acyl enzyme intermediates.
Journal article -
KJ Weissman
,
CJ Smith
,
U. Hanefeld
,
R Aggarwal
,
M Bycroft
,
J Staunton
,
PF Leadlay
Enantiospecific synthesis of tetrasubstituted delta-lactones.
Journal article -
AL Wilkinson
,
U. Hanefeld
,
B Wilkinson
,
PF Leadlay
,
J Staunton
Enantioselective synthesis of tetrasubstituted d-lactones.
Journal article -
AL Cutter
,
U. Hanefeld
,
B Wilkinson
,
PF Leadlay
,
J Staunton
Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues
Journal article -
A Ranganathan
,
M Timoney
,
PF Leadlay
,
M Bycroft
,
J Cortes
,
IP Thomas
,
B Wilkinson
,
L Kellenberger
,
U. Hanefeld
,
IS Galloway
,
J Staunton
Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.
Journal article -
I Böhm
,
IE Holzbaur
,
U. Hanefeld
,
J Cortes
,
J Staunton
,
PF Leadlay
Rational engineering of complex polyketide biosynthesis - Where do we begin?.
Conference paper -
PF Leadlay
,
J Staunton
,
AFA Marsden
,
AL Wilkinson
,
NJ Dunster
,
J Cortes
,
M Oliynyk
,
U. Hanefeld
,
MJB Brown