[...] Psoriasis is associated with a number of comorbidities of which some can be positively influenced by lifestyle changes. It is also known that dietary and relaxation interventions could be promising in improving psoriasis severity and the quality of life of patients with psoriasis. Knowledge on the motivation of psoriasis patients to change lifestyle and on differences in lifestyles of motivated versus unmotivated patients is essential for the development of targeted lifestyle interventions. However, evidence on this topic is scarce. Therefore, we (1) assessed the motivation of psoriasis patients to change their lifestyle and which lifestyle domains they are most willing to adapt, (2) assessed their current lifestyle in six lifestyle domains (physical activity, smoking, alcohol, diet, stress and sleep) and (3) compared the lifestyle of patients who are motivated with patients who are unmotivated or uncertain to change their lifestyle. [...]