With initiatives such as the European Green Deal establishing more stringent environmental requirements, there is an increasing need to develop aircraft technologies and sustainable aviation practices with reduced climate impacts. Additionally, conventional environmental Life Cycle Assessments (LCAs) often struggle to capture the dynamic and complex nature of aircraft operations; in particular, non-CO₂ in-flight impacts, which contribute significantly to climate change, are often overlooked. In this study, we improve a discrete-event LCA approach with a climate impact evaluation model and apply it to scenario analyses comparing different aircraft designs, fuel types, and flight schedules. Our findings reveal that, contrary to previous LCA studies, the climate impact per kilometre flown increases with longer flight distances and that an efficiently planned flight schedule can reduce the overall environmental impact. The study highlights the necessity of incorporating non-CO₂ effects and operational scenarios into LCA to achieve a more accurate understanding of aviation's environmental impact.