Regional-scale assessment of the damage caused by earthquakes to structures is crucial for post-disaster management. While remote sensing techniques can be of great help for a quick post-event structural assessment of large areas, currently available methods are limited to the detection of severely-damaged buildings. Furthermore, remote sensing-based assessment methods typically provide only qualitative results, as they lack integration with information on the building's behaviour in response to seismic-induced ground shaking. In this study, we developed a new methodology that uses airborne Light Detection And Ranging (LiDAR) data in combination with structural indicators of building response to provide a quantitative assessment of earthquake-induced damage at a regional scale. LiDAR datasets collected before and after an earthquake are used to measure residual displacements of building roofs. The resulting lateral drift estimations are used to quantify the level of damage for a specific building typology. Application to the LiDAR datasets collected before and after the 2014 earthquake in Napa Valley, California, demonstrates the capability of the proposed method to detect moderate levels of structural damage, proving its potential for faster and more accurate support to post-disaster management.@en