As many coastal regions experience a rapid increase in offshore wind farm installations, inter-farm distances become smaller, with a tendency to install larger turbines at high capacity densities. It is, however, not clear how the wake losses in wind farm clusters depend on the characteristics and spacing of the individual wind farms. Here, we quantify this based on multiple COSMO-CLM simulations, each of which assumes a different, spatially invariant combination of the turbine type and capacity density in a projected, future wind farm layout in the North Sea. An evaluation of the modelled wind climate with mast and lidar data for the period 2008–2020 indicates that the frequency distributions of wind speed and wind direction at turbine hub height are skillfully modelled and the seasonal and inter-annual variations in wind speed are represented well. The wind farm simulations indicate that for a typical capacity density and for SW winds, inter-farm wakes can reduce the capacity factor at the inflow edge of wind farms from 59 % to between 54 % and 30 % depending on the proximity, size and number of the upwind farms. The efficiency losses due to intra- and inter-farm wakes become larger with increasing capacity density as the layout-integrated, annual capacity factor varies between 51.8 % and 38.2 % over the considered range of 3.5 to 10 MW km−2. Also, the simulated efficiency of the wind farm layout is greatly impacted by switching from 5 MW turbines to next-generation, 15 MW turbines, as the annual energy production increases by over 27 % at the same capacity density. In conclusion, our results show that the wake losses in future wind farm clusters are highly sensitive to the inter-farm distances and the capacity densities of the individual wind farms and that the evolution of turbine technology plays a crucial role in offsetting these wake losses.