The thermospheric neutral density response to the 7–9 September 2017 storms is investigated based on the Swarm satellite observations and the thermosphere-ionosphere-electrodynamic general circulation model (TIEGCM) simulation. The Swarm data depicted a prominent interhemispheric asymmetry (IHA) in the afternoon sector during the second storm, a feature that was yet explained. Driven by realistic high-latitude electric potential and electron precipitation patterns, the TIEGCM is able to reproduce the observed storm-time neutral density response. The TIEGCM simulation reveals that the differences in the traveling atmospheric disturbances (TADs) is largely responsible for the observed IHA in the neutral mass density response at low and middle latitudes, whereas the difference in mean molecular mass between the two hemispheres may contribute to the IHA in neutral density at higher latitudes. The IHAs in TADs and mean molecular mass are attributed to the IHA in Joule heating dissipation on the night and dawn sides.