This thesis introduces a fragility-based framework in order to perform a custom assessment of the complex Eastern Scheldt storm surge barrier. By applying a conditional approach to loading parameters, the statistical dependency between failure mechanisms and structure elements can be described separately for the strength and loading part of the assessment, allowing for a reduction of the conservatism. This report applies this fragility-based assessment to assess the barrier on the failure mechanisms ‘height’ and ‘failure due to failing closure’.