Erosion-control measures in rivers aim to provide sufficient navigation width, reduce local erosion, or to protect neighboring communities from flooding. These measures are typically devised to solve a local problem. However, local channel modifications trigger a large-scale channel response in the form of migrating bed level and sediment sorting waves. Our objective is to investigate the large-scale channel response to such measures. We consider the lower Rhine River from Bonn (Germany) to Gorinchem (the Netherlands), where numerous erosion-control measures have been implemented since the 1980s. We analyze measured bed level data (1999–2020) around four erosion-control measures, comprising scour filling, bendway weirs, and two fixed beds. To get further insight on the physics behind the observed behavior, we set up an idealized one-dimensional numerical model. Finally, we study how the geometry and spacing of the measures affect channel response. We show that erosion-control measures reduce the sediment flux due to (a) lack of erosion over the measure and (b) sediment trapping upstream of the measure, resulting in downstream-migrating incision waves that travel tens of kilometers at decadal timescales. When the measures are in close proximity, their downstream effects may be amplified. We conclude that, despite fulfilling erosion-control goals at the local scale, erosion-control measures may worsen large-scale channel-bed incision.