Low-strength sediment layers within continental slope strata precondition submarine sediment for failure, potentially leading to destructive tsunamis. Using geophysical and Ocean Drilling Program well data, here we show that the glide planes of widespread submarine failures in the northern South China Sea, dated to the glacial stages following the Mid-Pleistocene Transition, have higher opal content, particle size, and porosity, which reduce the undrained shear strength. Cyclic weak-layer deposition, modulated at Milankovitch time scale, was controlled by increased ocean primary productivity and sedimentation rates linked to high-amplitude sea-level fluctuations and intensified winter monsoons. This study represents an important step forward for understanding how climate influences the formation of weak layers and the stability of continental slope globally.