Multi-energy networks facilitate the interactions of multiple energy carriers such as electricity, heat, cooling, and natural gas for manifold benefits in the construction and operation of energy systems. They also provide a unified platform to integrate and utilize various advanced energy technologies such as renewables, cogeneration, power-to-X, electric vehicles, and energy storage. The problem scale of multi-energy networks is increasing rapidly with the accelerated expansion and integration of regional and urban energy systems. For these reasons, the analysis and optimization of multi-energy networks are faced with significant challenges. New methods are urgently required to address the basic computational challenges in multi-energy networks such as the multi-temporal-spatial scales, nonlinearity, uncertainty, combinatorial property of mixed continuous and discrete variables, and the solving of large-scale systems in a multi-stakeholder context. This special issue mainly covers papers on the computational theories and methods that can be applied in multi-energy networks. The aim is to present a state-of-the-art collection of innovative models, algorithms, approaches, and tools for the control, operation, design, simulation, and analysis of multi-energy networks. The special issue provides an opportunity for researchers and practicing engineers to share their latest discoveries and best practices in these areas.