The development of clinical imaging techniques significantly improves diagnostic accuracy and provides guidance for personalized treatment of individuals. However, every single imaging modality has its distinct drawbacks that cannot fully fulfil the diagnosis requirement. Thus, rational combination of different imaging modalities can achieve more comprehensive information of disease and in this way provide better personalized treatment strategy. The hybrid PET/MRI has drawn increasing attention since its first clinical application. Imaging probes play an essential role in achieving qualified figures with accurate information of diseases. The application of nanotechnology promotes the development of versatile molecular probes for PET/MRI technique. Though there is an emerging clinical requirement, only a small number of multimodal PET/MRI probes have been investigated in preclinical research. Thus, this review tries to thoroughly summarize the nano-sized PET/MRI probes on their design, preparation and biological application. By discussing the strength and limitations of these current available PET/MRI multimodal probes, this work aims to figure out the further research direction and promote the possible clinic translation of the novel PET/MRI probes.@en

This paper presents the work on six single-stringer specimens manufactured using the card-sliding technique with non-crimp fabrics and adopting a Double-Double (DD) stacking sequence. These specimens, representative of sub-structure level components, are used to investigate post-buckling and failure in aerospace structures. Two specimens maintain a constant thickness cross-section, while four are tapered, two of which incorporate a Teflon insert in the stringer flange. All specimens are tested under compression loading conditions, inducing skin buckling, skin-stringer separation, and eventual collapse. Numerical simulations are validated by experimental results and serve to analyze the specimens behavior and the failure mode. The load versus displacement curves of both experimental tests and Finite Element Method (FEM) analyses are compared, along with the out-of-plane displacement field. Subsequently, the observed failure modes are discussed, focusing on the various mechanisms that occurred and considering the impact of flanges and stiffener tapering. Both the FEM simulations and experimental tests demonstrate good agreement, with the flanges tapering revealing notable results. This offers promising evidence of a viable solution to optimize aeronautical structures and enhance resistance to skin-stringer separation.@en