Rapid advancements in technology have led to the miniaturization of electronic devices which typically dissipate heat fluxes in the order of 100 W/cm². This has brought about an unprecedented challenge to develop efficient and reliable thermal management systems. Novel cooling technologies such as Two-Phase Thermosyphons that make use of nanofluids provide a promising alternative to the use of conventional systems. This article analytically estimates the effects caused by nanoparticles that deposit on the evaporator surface and their effect on the heat transfer process.