This study aimed to collect and analyze three-dimensional (3D) anthropometric data of Chilean workers to support the design of personal protective equipment (PPE) tailored to their physical characteristics. A total of 2016 participants, including Chileans and migrant workers, were measured using advanced 3D scanning technology. Significant sex-based and nationality-related differences were identified, with males exhibiting larger dimensions across most measurements. Comparisons with international datasets, including CAESAR, revealed unique anthropometric features among Chilean workers, highlighting substantial deviations in head and facial dimensions. These findings underscore the need for sex-specific and population-specific PPE designs, particularly given Chile's increasing workforce diversity. The results have practical implications for improving PPE fit, comfort, and safety in the workplace. This study provides a robust 3D anthropometric database that serves as a critical resource for manufacturers and safety professionals aiming to enhance occupational safety and equipment performance.