PR
Pierre Rousselot-Pailley
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Hybrid catalysis for enantioselective Baeyer-Villiger oxidation and stereoselective epoxidation
A Cp*Ir complex to fuel FMN and FAD reduction for flavoprotein monooxygenase modules
Journal article
(2023)
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Robert Röllig, Caroline E. Paul, Pierre Rousselot-Pailley, Selin Kara, Véronique Alphand
Taking advantage of the unique properties of two-component flavo-monooxygenases and the ability of [Cp*Ir(bpy-OMe)H]+ to transfer hydrides to reduce flavins, we extended the scope of the pH- and oxygen-robust iridium(iii)-complex to drive the enzymatic reaction of a FMN-dependent Baeyer-Villiger monooxygenase and a FAD-dependent styrene monooxygenase (respectively FPMO Group C and E), using formic acid as H-donor for NADH recycling.
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Taking advantage of the unique properties of two-component flavo-monooxygenases and the ability of [Cp*Ir(bpy-OMe)H]+ to transfer hydrides to reduce flavins, we extended the scope of the pH- and oxygen-robust iridium(iii)-complex to drive the enzymatic reaction of a FMN-dependent Baeyer-Villiger monooxygenase and a FAD-dependent styrene monooxygenase (respectively FPMO Group C and E), using formic acid as H-donor for NADH recycling.