In a global change context, governments in Europe want to promote alternative transports as inland navigation or railway instead of road transport. As example, in north of France, a shift of 20% from road transport to these alternative transport solutions is expected by 2050. Reaching this goal requires not only the delivery of new infrastructures and equipment, but also the design of efficient management strategies. By focusing on waterborne transport, it is thus necessary to improve the management of the inland navigation networks particularly the water resource. Indeed, the waterborne transport accommodation is strongly linked to the available water resource. This will be a challenging point in a global change context. The paper deals with the global change impacts on inland navigation networks. It aims at proposing new contributions as compared to past and current results of European projects on climate change and inland navigation. It appeared that the multi-scale modeling approach for inland navigation networks that was proposed during the last TRA Conference in Paris in 2014 is useful to determine the resilience of these networks and their ability to guarantee the navigation conditions during drought and flood periods. The proposed tools are developed to consider two space and time scales. The first approach is used to determine the water quantity that is necessary to accommodate the navigation during half a day, and the second allows the efficient control of the gates to keep the water level of each navigation reach close to its setpoint by rejecting disturbances and compensating the waves due to the lock operations. One example based on the real inland navigation network of the north of France is used to highlight the contributions of the multi-scale modeling approach.