Process and energy industries have been recognised as adopters of high levels of automation compared to other sectors. Nonetheless, human cognitive input still plays a critical role in the operation of process plants and replication of these cognitive capabilities remains a key challenge for advancing automation levels. In this paper, we provide an analysis of process and energy industries based on a scenario of reduced availability of skilled labour and increased demands for safety, sustainability, and resilience. We consider the different mechanical, sensing, situational awareness, and decision-making tasks involved in the operation of plants and map them to possible realisations of unmanned and autonomous systems. We discuss the implications of current technology capabilities and future technology development perspectives, the factors influencing the complexity of operation in process plants, and the importance of human-machine collaboration. As part of autonomous system capabilities, we consider adaptation as a key capability and we make a connection to adaptation of model-based solutions. We argue that reaching higher and wider levels of autonomy requires a rethink of the design processes for both the physical plants as well as the way automation, control, and safety solutions are conceptualised.