Molten Salt Reactors (MSR) are Generation IV nuclear systems in which the fuel is dissolved in a molten salt circulating through the primary system. There is growing interest in this advanced technology in Europe, but also in the US, China, South Korea, Japan and Russia, due to their inherently high safety level, flexibility, reliability, load-following capabilities, and potential for multi-recycling of materials contained in light-water reactors’ spent nuclear fuels. These advantages could position MSRs as ideal complements to other decarbonized energy sources in a future sustainable energy mix. In this respect, it is probably one of the most promising advanced technologies and, at the same time, the least mature and studied one. Two ongoing EURATOM-funded projects, MIMOSA and ENDURANCE projects are exploring molten salt reactors’ safety and performance features, as well as fuel cycle aspects, in order to assess and demonstrate their potential for future deployment in Europe. The MIMOSA and ENDURANCE projects have the common objective of improving the maturity of MSR technology. The MIMOSA project develops and analyses multi-recycling strategies for the European Union based on the use of MSR and demonstrates several key aspects of their technical feasibility and performance by both calculations and experimental investigations. The ENDURANCE project supports the safe operation and the development of Critical Technology Elements by connecting design developers and industry with universities and research centres while ensuring alignment with regulatory requirements. Whereas ENDURANCE is in its starting phase, MIMOSA has already delivered important results.