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document
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Leemans, Laura (author), Walter, Marc D. (author), Hollmann, F. (author), Schallmey, Anett (author), van Langen, L.M. (author)
Enantiopure β-amino alcohols constitute one of the most significant building blocks for the synthesis of active pharmaceutical ingredients. Despite the availability of a range of chiral β-amino alcohols from a chiral pool, there is a growing demand for new enantioselective synthetic routes to vicinal amino alcohols and their derivatives. In...
journal article 2019
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document
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Leemans, Laura (author), van Langen, Luuk (author), Hollmann, F. (author), Schallmey, Anett (author)
A concurrent bienzymatic cascade for the synthesis of optically pure (S)-4-methoxymandelonitrile benzoate ((S)-3) starting from 4-anisaldehyde (1) has been developed. The cascade involves an enantioselective Manihot esculenta hydroxynitrile lyase-catalyzed hydrocyanation of 1, and the subsequent benzoylation of the resulting cyanohydrin (S)-2...
journal article 2019
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