An Ultrasonically-Powered System for 1.06mm3 Implantable Optogenetics and Drug Delivery Dust
Kjeld Laursen (Aarhus University)
Milad Zamani (TU Delft - Electrical Engineering, Mathematics and Computer Science, Aarhus University)
Yasser Rezaeiyan (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Seyedsina Hosseini (Technical University of Denmark (DTU))
Tanmay Mondal (Tyndall National Institute)
Brian Corbett (Tyndall National Institute)
Abdel Mouttalib Ouagazzal (Aix Marseille Université)
Marianne Amalric (Aix Marseille Université)
Farshad Moradi (Aarhus University)
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Abstract
This brief presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μ LED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0-10 mW range, achieves start-up within 1.8~μ s at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to ( 500~μ m )3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μ LED for optogenetics), which translates to 0.11% total system efficiency.