An Ultrasonically-Powered System for 1.06mm<sup>3</sup> Implantable Optogenetics and Drug Delivery Dust

Journal article (2023)

Authors

Kjeld Laursen Aarhus University
M. Zamani Aarhus University, Bio-Electronics - EEMCS
Y. Rezaeiyan Bio-Electronics - EEMCS
Seyedsina Hosseini Technical University of Denmark
Tanmay Mondal Tyndall National Institute
Brian Corbett Tyndall National Institute
Abdel Mouttalib Ouagazzal Aix Marseille Université
Marianne Amalric Aix Marseille Université
Farshad Moradi Aarhus University
Research Group
Bio-Electronics (EEMCS) (TU Delft)
Copyright: © 2023 Kjeld Laursen, M. Zamani, Y. Rezaeiyan, Seyedsina Hosseini, Tanmay Mondal, Brian Corbett, Abdel Mouttalib Ouagazzal, Marianne Amalric, Farshad Moradi
DOI
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https://doi.org/10.1109/TCSII.2023.3289028
Piezoelectric Optogenetics Light emitting diodes Logic gates Rectifier Substrates Rectifiers Crystals Ultrasonic power transfer Bridge circuits Dust Optogenetic stimulation
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Published Date

2023

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Department

Microelectronics

Research Group

Bio-Electronics

Abstract

This brief presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μ LED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0-10 mW range, achieves start-up within 1.8~μ s at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to ( 500~μ m )3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μ LED for optogenetics), which translates to 0.11% total system efficiency.